Research

How the Vampire Breast Lift® procedure can

1. Improve sensation.

2. Correct irregularities & asymmetry

3. Work more safely than implants.

4. Reconstruct post surgery or mastectomy.

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   1. Research about how the Vampire Breast Lift® Procedure Improves Sensation of the Nipples...

**Effects of platelet-rich plasma on nerve regeneration in a rat model.
Küçük L, Günay H, Erbaş O, Küçük Ü, Atamaz F, Coşkunol E.
Acta Orthop Traumatol Turc. 2014;48(4):449-54. doi: 10.3944/AOTT.2014.13.0029.
PMID: 25230270

**Nerve regeneration: is there an alternative to nervous graft?
Sabongi RG, De Rizzo LA, Fernandes M, Valente SG, Gomes dos Santos JB, Faloppa F, Leite VM. fJ Reconstr Microsurg. 2014 Nov;30(9):607-16. doi: 10.1055/s-0034-1372477. Epub 2014 Aug 4.
PMID: 25089566

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**An autologously generated platelet-rich plasma suturable membrane may enhance peripheral nerve regeneration after neurorraphy in an acute injury model of sciatic nerve neurotmesis.
Giannessi E, Coli A, Stornelli MR, Miragliotta V, Pirone A, Lenzi C, Burchielli S, Vozzi G, De Maria C, Giorgetti M.
J Reconstr Microsurg. 2014 Nov;30(9):617-26. doi: 10.1055/s-0034-1372483. Epub 2014 May 16.
PMID: 24838385

**Platelet-rich plasma: a promising product for treatment of peripheral nerve regeneration after nerve injury.
Yu W, Wang J, Yin J.
Int J Neurosci. 2011 Apr;121(4):176-80. doi: 10.3109/00207454.2010.544432. Epub 2011 Jan 19.
PMID: 21244302

-->>Many more research papers about regenerating new nerve tissue<<--

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2. Research about how the Vampire Breast Lift® procedure can correct irregularities & asymmetry

(If you doubt the above photos were taken of the same person then expand the photo and you'll see that the moles match.)

How it was done (4 Steps, sometimes 5)...

1. 1. Surface with defect. Skin with underlying tissue of collagen, blood vessels, & nerve.
   2. Hyaluronic acid filler added. The filler is optional but helps with larger defects. The surface becomes flat.
   3. Blood-derived growth factors prepared with FDA-approved kit and then injected into the same area. These blood-derived growth factors include platelet-rich plasma. This fluid can be prepared at the bedside in about 15 minutes and then injected into the area.  The hyaluronic acid filler may sometimes be left out of the procedure (step 2) but the blood-derived growth factors should always be included and should be prepared with an FDA approved kit (not a lab kit made to measure blood components).
   4. Stem cells that rest in the bone marrow and surrounding tissue are recruited & activated by the blood-derived growth factors to migrate to the area to grow new healthier tissue (the body does this step, not the physician). In over 10,000 research papers with PRP in multiple tissue types, there has NEVER been one documented granuloma, fibrosis, necrosis, or neoplasia (cancer) from these growth factors in 1,000s of research papers. On the contrary, PRP has been used to IMPROVE blood flow, grow new nerve, fight infection, & remodel scars into normal tissue.
   5. The body resorbs the injected hyaluronic acid filler, if used, (which acts as a scaffolding for the recruited stem cells) and resorbs the platelet-rich fibrin matrix, but instead of the defect reappearing, the body fills the previous space with normal tissue (that grows from the pleuripotent stem cells). The new tissue looks smoother and displays a healthier color and shape. The following video demonstrates this process...

To understand how this can be possible, watch the following video (with before and after photos and interview) and read the research that follows the video...

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Here's more research showing what's going on...

1. Anthony P. Sclafani, MD; Steven A. McCormick, MD. Induction of Dermal Collagenesis, Angiogenesis, and Adipogenesis in Human Skin by Injection of Platelet-Rich Fibrin Matrix. Arch Facial Plast Surg. Published online October 17, 2011. [Biopsy-proven new blood vessel growth and new collegen using platelet-derived growth factors (using a single-spin centrifuge)]
2. Cervelli, Valerio MD; Lucarini, Lucilla MD.Use of Platelet-Rich Plasma and Hyaluronic Acid in the Loss of Substance with Bone Exposure. Advances in Skin & Wound Care: April 2011 - Volume 24 - Issue 4 - pp 176-181
3. Cervelli V1, Lucarini L, Spallone D, Brinci L, de Angelis B. Use of platelet rich plasma and hyaluronic acid on exposed tendons of the foot and ankle. J Wound Care. 2010 May;19(5):186, 188-90.
4. Ramos-Torrecillas J1, García-Martínez O1, De Luna-Bertos E1, Ocaña-Peinado FM2, Ruiz C3. Effectiveness of platelet-rich plasma and hyaluronic acid for the treatment and care of pressure ulcers. Biol Res Nurs. 2015 Mar;17(2):152-8. doi: 10.1177/1099800414535840. Epub 2014 May 20.
   

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   3.  Research about how the Vampire Breast Lift® can be safer than breast implants...

-->>First, it's important to know that PRP (what's used in the Vampire Breast Lift® procedure) has NEVER been associated with malignancy or any serious side effect EVER (in over 10,000 research papers in multiple tissue types).

Though the Vampire Breast Lift® methods have NEVER been associated with any serious side effects, on the other hand, BREAST IMPLANTS (not the Vampire Breast Lift®) have been associated with all of the following...

(1) Implants associated with increased risk of cancer (click now to read about women treated with chemo after implants), Here's the FDA's current investigation and recommendations about this rare but real phenomenon of cancer after implants.
(2) Implants can cause encapsulation, Here's another research study demonstrating how the encapsulation (occurs in around 1 in 10 women who get implants) could help trigger breast cancer--->>click to read Our provider group is looking at using the Vampire Breast Lift® as a possible way to treat the encapsulation that occurs in around 10% of breast implant recipients before the capsule converts to cancer. Since PRP helps fight both infection and decrease the autoimmune response, biologically this makes sense. This is why some people have stretched things to say use the Vampire Breast Lift® procedure to help prevent cancer.  We do not have nearly enough research to say that yet!
(3) Implants can cause necrosis of the nipple,

Here's research showing how the Vampire Breast Lift® can help heal necrosis.

(4) Implants can cause loss of sensation of the nipple,
(5) Implants can cause infection,
(6) Implants can cause dehiscence,
(7) Implants can rupture.  

-->>We are NOT saying that breast implants are not a good option for many women (complication rate is less than 5% or less than 1 in 20).

-->>We are saying that Implants have been associated with thousands of serious complications (including cancer)
-->>While on the other hand, the material used in the Vampire Breast Lift® procedure, PRP (by thousands of research papers in multiple tissue types (even when using the method to repair the breast after mastectomy for breast cancer) has NEVER been associated with one serious side effect--EVER!

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3. How the Vampire Breast Lift® is being used post-mastectomy...

For restoration of the breast, plastic surgeons commonly mix PRP with fat and transfer the mixture (fat + PRP) to the breast (widely done since 2009 to repair women post op from mastectomy for cancer).  Even though there is some evidence that PRP could help prevent breast cancer, and even though PRP (what's used in the Vampire Breast Lift®) has been shown in multiple research studies to be safe when mixed with fat and transferred to the breast (even in women after breast cancer), we have no direct studies showing that it actually helps prevent breast cancer.  Doctors have used PRP to help restore breast tissue for years and  that has been done without any record of serious side effect ever.  And biochemically, PRP should help prevent cancer, but until those studies are done, PRP should not be used to help prevent cancer.

-->>Here's an article by the American Society of Plastic Surgeons describing fat transfer as safe.

 It's widespread for plastic surgeons to transfer fat to the breast mixed with PRP to reconstruct the breast surgery in a woman who has suffered with breast cancer--and this is considered safe (click to read recent article).

Here's another research article that review the use of fat (usually mixed with PRP) for repair of the breast after breast cancer and how it's considered safe by gynecologists (click to read).

Notice that in the article about safety about using fat/with PRP after cancer that the woman must still continue to follow up with her breast surgeon.  And there is not mention of prevention of breast cancer.

Here's another recent article published showing the safety of fat for restoration of the breast post surgery for breast cancer (click to read). If you notice this quote from the article, there was a slight DECREASE in incidence with the transfer of fat to the breast (which again would impart the effects of PRP)...

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"As shown in Figure 1, the cumulative 3-year and 5-year locoregional recurrence rates were 0.3 percent and 1.6 percent, respectively, for the cases (lipofilling) and 1.3 percent and 4.1 percent, respectively , for the controls (no lipofilling) [That's 1/2 the recurrence rate with the fat/growth factors]. The incidence of locoregional recurrence was 0.25 cases per 100 person-years for the cases and 0.65 cases per 100 person-years for the controls (p = 0.455). In the 305 healthy breasts reconstructed with lipofilling after risk-reducing mastectomy, no cases of breast cancer were observed during the follow-up period."
End Quote.

Even though there may be biochemical reasons why PRP (the Vampire Breast Lift®) may be protective to the breast, the woman should still be followed by her surgeon and not use PRP to help prevent cancer ...only to restore the breast to a more natural shape (either alone or mixed with fat).

One of the side effects of fat transfer of fat to the breast is that the fat will simply die and there will be left no improvement in appearance.  To help survival of the transferred fat, the fat is usually mixed with platelet-rich plasma (PRP). For years, oral surgeons have used PRP to help with healing in reconstructing the mouth of a man undergoing oral surgery in the face of cancer of the jaw.  With multiple papers, no one has demonstrated PRP as a carcinogen (which makes sense since PRP is normally in our blood and is generated as part of the normal healing process and so would ENHANCE the immune system and so in theory should help protect against cancer (though we have no proof that PRP would prevent cancer in the breast).

So, even though we have over 10,000 research papers about PRP and not one EVER showed development of neoplasia (cancer) we should use PRP only to restore tissue, not for prevention of cancer.

We consider breast implants to be a viable and accepted procedure.  Yet, breast implants can cause infection, dehiscence, necrotic (dead) nipples, loss of sensation of nipples, irregularities, encapsulation, and can break leaking into the tissue...all these things happen (click to read!) This does not mean that breast implants are not a useful and "relatively safe" procedure.  The procedure is done over 200,000 times per year in the US.  Most of the known side effects occur in less than 5% (less than 1 in 20). But, still these are KNOWN side effects and we are putting a foreign material into a tissue that's known to develop cancer and we know that chronic irritation or inflammation (which can occur from a foreign material in the body) can be a trigger for cancer. Still, implants are a safe option.

Yet, PRP is used to treat scaring, is known to enhance the immune system (as in fight infection and in theory fight cancer cells) --and PRP tends to DECREASE inflammation (click here to read over 250 research projects on the subject) and PRP has never been associated with a serious side effect EVER (it can even be use in pregnancy) ...and PRP is being done already (injected into the breast along with fat with fat transfer to the breast) and considered  considered safe for YEARs. 

In short, if fat mixed with PRP is safe even in a woman trying to stay cancer free post treatment for breast cancer, then PRP alone should also be safe (we just avoid the discomfort of the liposuction needed to obtain the fat and use PRP alone in most cases of the Vampire Breast Lift® procedure).

--->>>There are no long-term 40 year double blind cross over studies with PRP, fat with PRP, or with implants.  We only know what we know and that is that there has never been a neoplasia or serious side effect associated with PRP ever--and on the contrary, PRP is used frequently to enhance the healing of damaged and scarred tissue.

So, if a woman wants an increase in cleavage or improvement of sensation of the nipple with PRP alone and to avoid surgery, then why should she more afraid of the material with a 10-year history of not one serious side effect than of a procedure with a much higher rate of complication (implants)?

We don't think she should.

We think she should consider all three procedures to be relatively safe and undergo the procedure that's best for her purposes: Either (1) implants (for the most volume), (2) fat transfer to the breast (mixed with PRP) for less volume, or (3) the Vampire Breast Lift® (a way of using PRP alone) for a polishing effect and for touching up the breast in the cleavage area without increasing breast size).

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Important-->>Only consult with certified providers...
 This procedure should only be done by providers listed on this website.  These providers understand the use of devices approved by FDA for the use of preparing PRP for injection back into the body. PRP has never been associated with a serious side effect (EVER) but for optimal RESULTS  the provider should understand our method for preparing PRP, for using FDA approved devices, and understand how to do the procedure safely and comfortably.  All certified providers are listed on the following website...

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Mixing Fat with PRP-Safe & It Works!

1.Cervelli V, Palla L, Pascali M, et al. Autologous platelet-rich plasma
mixed with purified fat graft in aesthetic plastic surgery. Aesthetic Plast
Surg 2009;33:716-21.
2. Cervelli V, Gentile P, Scioli MG, et al. Application of platelet-rich plasma
in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part
C Methods 2009;15:625-34.
3.Nakamura S, Ishihara M, Takikawa M, et al. Platelet-rich plasma (PRP)
promotes survival of fat-grafts in rats. Ann Plast Surg 2010;65:101-6.
4.Gentile P, Orlandi A, Scioli MG, et al. A comparative translational study:
the combined use of enhanced stromal vascular fraction and plateletrich
plasma improves fat grafting maintenance in breast reconstruction.
Stem Cells Transl Med 2012;1:341-51.
5.Choi J, Minn KW, Chang H. The Efficacy and safety of platelet-rich
plasma and adipose-derived stem cells: An update. Arch Plast Surg
2012;39:585-92.
6. Sommeling CE, Heyneman A, Hoeksema H, et al. The use of plateletrich
plasma in plastic surgery: a systematic review. J Plast Reconstr
Aesthet Surg 2013;66:301-11.

More Related Research...

Sentinal Nodes and PRP after Breast Cancer<--

1. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007;9(3):174-183.

2. Sclafani AP, Romo TR III, Ukrainsky G, et al. Modulation of wound response and
soft tissue ingrowth in synthetic and allogeneic implants with platelet concentrate. Arch Facial Plast Surg. 2005;7(3):163-169.

3. O'Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous
platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen. 2008;16(6):749-756.

 

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4. Cervelli, Valerio MD; Lucarini, Lucilla MD.Use of Platelet-Rich Plasma and Hyaluronic Acid in the Loss of Substance with Bone Exposure. Advances in Skin & Wound Care: April 2011 - Volume 24 - Issue 4 - pp 176-181 [This one shows using the same techniques used in the Vampire Facelift (R) procedure to grow new skin WHERE THERE IS NO SKIN]

5. Redaelli, Alessio. Face and neck revitalization with Platelet-rich plasma (PRP): clinical
outcome in a series of 23 consecutively treated patients. Journal of Drugs in Dermatology - May 1, 2010

6. Azzena B, Mazzoleni F, Abatangelo G, Zavan B, Vindigni V. Autologous platelet-rich [Using Regen prepared platelet-derived growth factors (a single-spin centrifuge) to rejuvenate the face & neck]
plasma as an adipocyte in vivo delivery system: case report. Aesthetic Plast Surg. 2008;32(1):155-161.

7. Cervelli V, Gentile P, Grimaldi M. Regenerative surgery: use of fat grafting combined
with platelet-rich plasma for chronic lower-extremity ulcers. Aesthetic Plast Surg. 2009;33(3):340-345.

8. Cervelli V, Palla L, Pascali M, De Angelis B, Curcio BC, Gentile P. Autologous
platelet-rich plasma mixed with purified fat graft in aesthetic plastic surgery. Aesthetic Plast Surg. 2009;33(5):716-721.

9. Cervelli V, Gentile P. Use of cell fat mixed with platelet gel in progressive hemifacial atrophy. Aesthetic Plast Surg. 2009;33(1):22-27.

10. Cervelli V, Gentile P, Scioli MG, et al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009; 15:1-9.

11. Sclafani AP. Platelet-rich fibrin matrix for improvement of deep nasolabial folds.

J Cosmet Dermatol. 2010;9(1):66-71.

12. Sclafani AP. Applications of platelet-rich fibrin matrix in facial plastic surgery.

Facial Plast Surg. 2009;25(4):270-276.

13. Sclafani AP. Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery [published online February 21, 2011]. Arch Facial Plast Surg. 2011;13(4):247-251.

14. Kakudo N, Minakata T, Mitsui T, Kushida S, Notodihardjo FZ, Kusumoto K.

Proliferation-promoting effect of platelet-rich plasma on human adiposederived stem cells and human dermal fibroblasts. Plast Reconstr Surg. 2008; 122(5):1352-1360.

15. Oh DS, Cheon YW, Jeon YR, Lew DH. Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study. Dermatol Surg. 2011;37(5):619-625.

16. Danielsen P, Jørgensen B, Karlsmark T, Jorgensen LN, Agren MS. Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial. Plast Reconstr Surg. 2008;122(5):1431-1440.

17. Anitua E, Sa´nchez M, Zalduendo MM, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162-170.

18. Carroll RJ, Arnoczky SP, Graham S, O'Connell SM. Characterization of Autologous Growth Factors in Cascade Platelet-Rich Fibrin Matrix (PRFM). Edison, NJ: Musculoskeletal Transplant Foundation; 2005. Publication No. 128-XM 307C5.

19. Anthony P. Sclafani, MD; Steven A. McCormick, MD. Induction of Dermal Collagenesis, Angiogenesis, and Adipogenesis in Human Skin by Injection of Platelet-Rich Fibrin Matrix. Arch Facial Plast Surg. Published online October 17, 2011. [Biopsy-proven new blood vessel growth and new collagen using platelet-derived growth factors (using a single-spin centrifuge)]

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